The researchers suggest that reaching menopause(menopause heart disease) before age 40 is related to several heart conditions in women.
The study was presented at the 2019 Scientific Sessions of the American Heart Association in Philadelphia.
In the largest single study to date of various risks of heart disease in relation to age at menopause, the researchers used the UK Biobank to examine data from more than 144,000 postmenopausal women (average age 60), including around of 4,900 women who experienced menopause “naturally.” before age 40 and around 640 who entered menopause before age 40 after their ovaries were surgically removed.
Women who reach menopause before age 40 are at risk of heart disease
During an average of seven years of follow-up, researchers found that women who had experienced premature menopause were significantly more likely to develop risk factors for conventional heart disease, such as high blood pressure, high levels of “bad” cholesterol, and type diabetes.
Even after taking into account conventional risk factors, women with premature menopause still had a significantly higher risk of coronary artery disease, heart failure, thickening and narrowing of the aortic valve, atrial fibrillation (an abnormal heart rhythm) and formation of blood clots in the legs or light.
The risks of heart disease were higher for women who experienced menopause due to surgery compared to natural menopause. Part of this risk difference can be explained by differences in risk factors for cardiovascular disease.
The fact that a woman took or not hormones for menopausal symptoms did not change cardiovascular risks.
Menopausal age before age 50 had a dose-dependent effect on the risk of cardiovascular disease, which means that the risk continued to increase with younger menopausal ages and the increase in cardiovascular risks lasted decades after menopause.
“Our study reinforces the importance of the history of menopause in informing the risk of a woman’s future heart disease,” said Michael Honigberg, MD, MPP, lead author of the study and a cardiology fellow at Massachusetts General Hospital and the Harvard Medical School in Boston.
“Women should ensure that their doctor knows their history of menopause, particularly if they experienced it before age 40. The history of premature menopause should encourage doctors to refine the estimated future risks of the patient’s heart disease and work to reduce your risks of heart disease. ” Honigberg
“Whether or not the medications are justified, eating a heart-healthy diet and exercising regularly can be especially important for women with a history of premature menopause,” said Honigberg.